PHARMACOKINETIC AND PHARMACODYNAMIC MODELLING IN ADMINISTRATION OF ERYTHROPOIETIN

摘要

FIELD: medicine, pharmacology. ^ SUBSTANCE: invention relates to method for assay of optimized regimens in dosing erythropoietin (EOR). Invention proposes a system for election of one or some regimens in dosing by using pharmacokinetic/pharmacodynamic (PK/PD) as a model for assay of PK/PD pattern regimens. Then method involves selection of such regimen that provides the serum concentration of EOR exceeding its before administration for 5-30 days between administrations of EOR. Invention provides optimal applying EOR for correction of blood indices changes and treatment of diseases associated with them. ^ EFFECT: improved and valuable modeling method. ^ 50 cl, 81 dwg, 2 tbl, 8 ex