摘要 |
FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a new method for preparing naproxen nitroxyalkyl esters. Invention describes a method for preparing 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid nitroxyalkyl with enantiomeric excess exceeding or equal to 97% but preferably exceeding or equal to 98%. Method involves interaction of 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid halogen anhydride of the formula A-Hal wherein A represents acyl residue of indicated acid with aliphatic nitroxyalkyl alcohol of the formula HO-Y-ONO2 wherein Y means linear or optionally branched (C2-C5)-alkylene in inert organic solvent in the presence of inorganic base to obtain the corresponding 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid nitroxyalkyl ester of the formula A-O-Y-ONO2 wherein A and Y are given above. Also, invention describes 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid 4-nitroxybutyl ester with enantiomeric excess of (S)-form in limits from 97% to 98% but preferably above 98%. Invention provides the development of a new method for preparing naproxen nitroxyalkyl esters with enhanced level of enantiomeric excess. ^ EFFECT: improved preparing method. ^ 6 cl, 9 ex |