COMPOUNDS THAT MODULATE THE GLUCAGON RESPONSE AND USES THEREOF

摘要

Peptides that modulate the glucagon response in a mammal are provided. The peptides comprise an amino acid sequence of between about 5 and about 10 amino acids in length that corresponds to the sequence of an extracellular membrane insertion region of a mammalian glucagon receptor, wherein at least one amino acid of the peptide has a D-configuration. Methods of preparing the peptides and the use of the peptides in the amelioration, treatment and/or prevention of glucagon-mediated conditions and diseases such as hyperglycemia, diabetes and obesity are also provided.