发明名称 |
METHODS FOR IDENTIFYING COMPOUNDS FOR INHIBITING FEVER |
摘要 |
Microsomal prostaglandin E synthase-1 (mPGES-1) catalyses the terminal step in the synthesis of prostaglandin E2 (PGE2) in the brain. In the absence of mPGES-1, animals do not develop immune-induced fever, but retain a normal pyretic response to central administration of PGE2. Inhibitors of PGES-1 can be used for treating fever and other PGE2-dependent reactions. Assays for inhibitors of mPGES-1 are provided. |
申请公布号 |
WO2005024059(A2) |
申请公布日期 |
2005.03.17 |
申请号 |
WO2004EP09734 |
申请日期 |
2004.09.01 |
申请人 |
KAROLINSKA INNOVATIONS AB;BLOMQVIST, ANDERS;JAKOBSSON, PER-JOHAN;ENGBLOM, DAVID |
发明人 |
BLOMQVIST, ANDERS;JAKOBSSON, PER-JOHAN;ENGBLOM, DAVID |
分类号 |
A61K38/52;A61K48/00;C12N9/90;C12N15/85;C12Q1/533;G01N33/50 |
主分类号 |
A61K38/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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