METHOD OF FORMING AND USING SOLID-PHASE SUPPORT

摘要

A method of forming a solid-phase support (30), the method including the steps of providing a substrate (32) having a reaction vessel (33), dispensing a particle (31) in the reaction vessel (33), and permanently bonding the particle in the substrate (32) within the reaction vessel (33). The particle (31) may include a microbead. The particle (31) may include controlled pore glass. A method of synthesis is also disclosed that includes including the steps of providing a solid-phase support (30) including a particle (31) embedded to the substrate (32) adjacent a surface of substrate, the particle (31) being functionalized to covalently attach an intermediate compound of a synthetic reaction, dispensing a liquid including a reagent to the solid-phase support (31) to effect the synthetic reaction, and removing the liquid from the solid-phase support (31) by centrifugation, whereby the intermediate compound remains attached to the substrate (32) by the particle (31).