发明名称 |
METHODS FOR IDENTIFYING INHIBITORS |
摘要 |
Vif binds to APOBEC3G and induces its rapid degradation, thus eliminating it from cells and preventing its incorporation into HIV-1 virions. Vif contains two domains, one that binds APOBEC3G and another with a conserved SLQ(Y/F)LA motif that mediates APOBEC3G degradation by a proteasome-dependent pathway. Provided herein are methods of exploiting these discoveries to develop compounds useful to inhibit Vif degradation of APOBEC3G, and thereby inhibit viral infection and/or replication.
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申请公布号 |
CA2525972(A1) |
申请公布日期 |
2005.03.17 |
申请号 |
CA20042525972 |
申请日期 |
2004.05.03 |
申请人 |
OREGON HEALTH & SCIENCE UNIVERSITY |
发明人 |
ROSE, KRISTINE M.;MARIN, MARIANA;KABAT, DAVID;KOZAK, SUSAN L. |
分类号 |
C07K14/16;C12N9/78;C12Q1/70;G01N33/50 |
主分类号 |
C07K14/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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