发明名称 |
Methods for direct visualization of active synapses |
摘要 |
A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells allows visualization of an active synapse. Also, a method for screening molecules capable of modulating synapse activity is provided. A kit useful for the early diagnosis of neurodegenerative disease comprises a biomarker comprising at least fragment C of tetanus toxin and a reporter protein.
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申请公布号 |
US2005060761(A1) |
申请公布日期 |
2005.03.17 |
申请号 |
US20040817961 |
申请日期 |
2004.04.06 |
申请人 |
VAZQUEZ-MARTINEZ RAFAEL;BRULET PHILIPPE |
发明人 |
VAZQUEZ-MARTINEZ RAFAEL;BRULET PHILIPPE |
分类号 |
A61K38/00;A61K47/48;C07K14/33;(IPC1-7):C12Q1/00;A01K67/027 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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