Vif binds to APOBEC3G and induces its rapid degradation, thus eliminating it from cells and preventing its incorporation into HIV-1 virions. Vif contains two domains, one that binds APOBEC3G and another with a conserved SLQ(Y/F)LA motif that mediates APOBEC3G degradation by a proteasome-dependent pathway. Provided herein are methods of exploiting these discoveries to develop compounds useful to inhibit Vif degradation of APOBEC3G, and thereby inhibit viral infection and/or replication.
申请公布号
WO2005024422(A2)
申请公布日期
2005.03.17
申请号
WO2004US13722
申请日期
2004.05.03
申请人
OREGON HEALTH & SCIENCE UNIVERSITY;KABAT, DAVID;MARIN, MARIANA;KOZAK, SUSAN, L.;ROSE, KRISTINE, M.
发明人
KABAT, DAVID;MARIN, MARIANA;KOZAK, SUSAN, L.;ROSE, KRISTINE, M.