发明名称 |
POLYAMINE-METAL CHELATOR CONJUGATES |
摘要 |
Many metal chelators have polar or charged functional groups, which render them difficult to transport across a cell membrane. Polyamine-metal chelator conjugates of the invention are compounds comprising a first moiety which is a metal chelator and a second moiety which is a polyamine, where the polyamine moiety includes three or more nitrogen atoms which are capable of being positively charged at physiological pH. A spermine-L1 conjugate has been sho wn to accumulate in L1210 cells several hundred fold more than the unconjugated L1 chelator.
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申请公布号 |
CA2538159(A1) |
申请公布日期 |
2005.03.17 |
申请号 |
CA20042538159 |
申请日期 |
2004.09.09 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
BERGERON, RAYMOND J., JR. |
分类号 |
A61K47/48;A61K31/132 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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