USE OF POLYMORPHISMS OF EOTAXIN GENES FOR PREDICTING AND DIAGNOSING ASTHMA

摘要

Use of polymorphisms of eotaxin genes for predicting and diagnosing asthma is provided, thereby verifying that the occurrence of asthma is related to EOT2+1265A>G polymorphism, and sensitivity for high IgE formation is related to EOT1+123A1a>Thr polymorphism, so that the occurrence of asthma can be predicted by detecting relation between the occurrence of asthma and eotaxin 2 polymorphism and relation between the sensitivity for high IgE formation and eotaxin 1 polymorphism. The polymorphisms of eotaxin genes for predicting and diagnosing asthma are provided, the polymorphisms include EOT2+1265A>G or EOT1+123A1a>Thr polymorphism; and the EOT1+123A1a>Thr polymorphism is dose-dependently related to sensitivity for serum total IgE formation in a patient suffering from asthma. A method for predicting and diagnosing asthma comprises measuring polymorphisms of eotaxin genes.