| 摘要 |
A therapeutic or preventive agent for nausea/vomiting which contains as an active ingredient either a morphinane derivative represented by the general formula (I): (I) (wherein R1 represents cyclopropylmethyl, etc.; R2 and R3 each represents hydroxy, methoxy, etc.; R4 and R5 are bonded to each other to form -O-, etc.; R6 represents hydrogen, etc.; and Q represents (II) which has been optionally substituted, etc., provided that X represents NH, NMe, etc.) or a pharmacologically acceptable acid addition salt thereof. The compound or salt is useful in a medicine widely applicable to vomiting caused by drugs having emetic activity, especially in a therapeutic or preventive agent for nausea/vomiting induced by mu agonists represented by morphine.
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