摘要 |
The present invention relates to the use of 2-amino-benzothiazoles, having the formula (I) wherein R1 is hexahydrofuro[2,3-b]furanyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, or phenyl optionally substituted with one or more substituents independently selected from C1-6-alkyl, hydroxy, amino, halogen, aminoC1-4-alkyl and mono-or di(C1-4alkyl)amino; R 2 is hydrogen or C1-6alkyl; L is a direct bond, -0-, C1- 6alkanediyl-O- or -O-C1-6alkanediyl; R3 is phenylC1-4alkyl; R4 is C1-6alkyl; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1- 6alkyl; in the manufacture of a medicament useful for inhibiting mutant HIV protease in a mammal infected with said mutant HIV protease. It also relates to novel compounds of formula (I).
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申请人 |
TIBOTEC PHARMACEUTICALS LTD. |
发明人 |
SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN;WIGERINCK, PIET TOM BERT PAUL;GETMAN, DANIEL P. |