发明名称 |
Non-nucleoside reverse transcriptase inhibitors |
摘要 |
Disclosed herein are compounds of formula Ar<1>-X-W-Ar<2 >wherein Ar<1 >and Ar<2 >represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)-N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.
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申请公布号 |
US2005054639(A1) |
申请公布日期 |
2005.03.10 |
申请号 |
US20030719369 |
申请日期 |
2003.11.21 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
SIMONEAU BRUNO;FAUCHER ANNE-MARIE;LANDRY SERGE;O'MEARA JEFFREY;THAVONEKHAM BOUNKHAM;YOAKIM CHRISTIANE |
分类号 |
A61K31/167;A61K31/41;A61K31/4164;A61K31/4178;A61K31/4184;A61K31/4192;A61K31/4439;C07D233/84;C07D235/28;C07D249/12;C07D257/04;C07D257/06;C07D307/54;C07D401/04;C07D401/12;C07D403/12;C07D405/12;C07D409/12;(IPC1-7):A61K31/541;A61K31/537;A61K31/496;A61K31/427;A61K31/422;A61K31/417 |
主分类号 |
A61K31/167 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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