ACETYLENIC ARYL SULFONATE HYDROXAMIC ACID TACE AND MATRIX METALLOPROTEINASE INHIBITORS

摘要

Hydroxamic acids having the formula (B) are useful in treating disease conditions mediated by TNF-(x, euch as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart hHure, inflammatory disease of the central nervous system, inflammatory bowel disease or HIV infection.