СИСТЕМЫ С РЕГУЛИРУЕМОЙ ДОСТАВКОЙ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ОБЕСПЕЧИВАЮЩИЕ ПЕРЕМЕННЫЕ СКОРОСТИ ВЫСВОБОЖДЕНИЯ

摘要

A controlled release dosage form with variable release rates comprising: 1) a bilayer or multilayer tablet core in which at least one of the layers contains one or more pharmaceutically active ingredients and at least one of the layers contains one or more rate controlling polymers; 2) a substantially insoluble casing extended over the tablet core covering the majority of tablet surface but leaving a portion of one layer of the table core exposed (exposed layer), the casing resulting from electrostatic deposition of a powder comprising fusible particles onto the tablet core and fusing the particles to form a thin film.