发明名称 |
RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK |
摘要 |
The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for use in screening potential mimics or modulators thereof. A method for screening for agents capable of affecting the activity of GSK3 is also disclosed. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK. There is also provided a process for activating RAC-PK comprising treatment thereof with a phosphatase inhibitor.
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申请公布号 |
US2005053594(A1) |
申请公布日期 |
2005.03.10 |
申请号 |
US20040823433 |
申请日期 |
2004.04.12 |
申请人 |
ALESSI DARIO;ANDJELKOVIC MIRJANA;COHEN PHILIP;CRON PETER DAVID;CROSS DARREN;HEMMINGS BRIAN A. |
发明人 |
ALESSI DARIO;ANDJELKOVIC MIRJANA;COHEN PHILIP;CRON PETER DAVID;CROSS DARREN;HEMMINGS BRIAN A. |
分类号 |
A61K38/00;C07K14/47;C12N9/12;C12Q1/42;C12Q1/48;(IPC1-7):A61K38/48 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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