IN VITRO GENERATION OF GABAERGIC NEURONS FROM EMBRYONIC STEMCELLS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS

摘要

The present disclosure is directed to improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells such as GABAergic neurons from pluripotent stem cells, for example embryonic stem cells. Using the disclosed methods, cell populations containing a high proportion of GABAergic neurons have been isolated. The neuroprogenitor cell s and terminally differentiated cells of the present disclosure can be generat ed in large quantities, and therefore may serve as an excellent source for cell replacement therapy in neurodegenerative disorders and neuronal diseases suc h as stroke, ischemia, epilepsy, and Huntington's disease.