发明名称 |
INDUCTION OF ANTIVIRAL NEUTRALIZING ANTIBODIES IN HUMANS ANDANIMALS |
摘要 |
<p>The invention relates to immunogenic constructs that in principle comprise two different domains of the transmembrane envelope protein of enveloped viruses including retroviruses including HIV, a pharmaceutical agent for inducing humoral neutralizing immune responses to viral infections and to a kit for the detection of antibodies and viral antigens. The invention also relates to a method for inducing an antibody response and to a method for the passive immunization of an organism using neutralizing antibodies that were obtained using the above-mentioned immunogenic constructs. Finally, the invention relates to a bioassay for detecting viral infection and for detecting the production of neutralizing antibodies.</p> |
申请公布号 |
CA2548483(A1) |
申请公布日期 |
2005.03.10 |
申请号 |
CA20042548483 |
申请日期 |
2004.08.26 |
申请人 |
BRD, VERTRETEN DURCH DAS BUNDESMINISTERIUM FUER GESUNDHEIT UND SOZIALE S ICH |
发明人 |
FIEBIG, UWE;KARLAS, ALEXANDER;DENNER, JOACHIM;KURTH, REINHARDT;SCHMOLKE, MIRCO |
分类号 |
C07K14/16;A61K38/16;A61K39/21;A61P31/14;C07K14/005;C07K16/10;C12N15/49;G01N33/569;G01N33/68 |
主分类号 |
C07K14/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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