BINDER COMPOSITION AND METHOD FOR PROCESSING POORLY COMPRESSIBLE DRUGS INTO TABLETS OF PREDETERMINED HARDNESS AND FRIABILITY

摘要

Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10°C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.