The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of CL and the interchain cysteine of CH1 have been replaced with another amino acid.
申请公布号
WO2005003170(A3)
申请公布日期
2005.03.10
申请号
WO2004GB02870
申请日期
2004.07.01
申请人
CELLTECH R & D LIMITED;HUMPHREYS, DAVID, PAUL;HEYWOOD, SAM, PHILIP;CARRINGTON, BRUCE
发明人
HUMPHREYS, DAVID, PAUL;HEYWOOD, SAM, PHILIP;CARRINGTON, BRUCE
