| 摘要 |
The present invention relates to method of treating a gastrointestinal motility disorder in a subject in need of treatment comprising coadministeri ng to said subject a first amount of a compound having 5-HT3 receptor agonist activity or a pharmaceutically acceptable salt, hydrate or solvate thereof; and a second amount of at least one gastric acid suppressing agent (e.g., a proton pump inhibitor, an H2 receptor antagonist or a pharmaceutically acceptable salt, hydrate or solvate thereof, or an acid pump antagonist or pharmaceutically acceptable salt, hydrate or solvate thereof) wherein the first and second amounts together comprise a therapeutically effective amoun t. In particular, the method is for treating GERD, including nocturnal GERD. Th e invention further relates to a method of treating nocturnal GERD comprising administering to a subject in need thereof a therapeutically effective amoun t of a compound having 5-HT3 receptor agonist activity or a pharmaceutically acceptable salt, hydrate or solvate thereof. The invention further relates t o a method of increasing esophageal motility in a subject in need thereof. The method of increasing esophageal motility can be achieved by administration o f a compound having 5-HT3 receptor agonist activity or a pharmaceutically acceptable salt, hydrate or solvate thereof. The coadministration can also b e used to increase esophageal motility.
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