发明名称 |
Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP) |
摘要 |
The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
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申请公布号 |
US2005054631(A1) |
申请公布日期 |
2005.03.10 |
申请号 |
US20040933098 |
申请日期 |
2004.09.01 |
申请人 |
AVENTIS PHARMACEUTICALS INC. |
发明人 |
JIANG JOHN Z.;KOEHL JACK ROGER;MEHDI SHUJAATH;MOORCROFT NEIL DAVID;MUSICK KWON YON;WEINTRAUB PHILIP MARVIN;EASTWOOD PAUL ROBERT |
分类号 |
A61K31/404;A61K31/454;A61K31/4745;A61K31/496;A61K31/503;A61K31/5377;A61K31/541;A61K31/55;A61P9/10;C07D209/40;C07D401/04;C07D401/10;C07D401/12;C07D403/04;C07D403/10;C07D405/12;C07D405/14;C07D409/04;C07D471/04;C07D487/08;(IPC1-7):A61K31/55;A61K31/537;A61K31/474 |
主分类号 |
A61K31/404 |
代理机构 |
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地址 |
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