Huntington's disease gene transcriptional factors

摘要

The present invention provides an isolated and purified transcriptional factors for the Huntington's disease gene, which have the amino acid sequence of SEQ ID No. 2 or SEQ ID No. 4 as a protein factor associated with the transcription of the Huntington's disease gene product. The invention also provides a polynucleotides encoding such transcriptional factors. These inventions are useful in the development of a therapeutic technology for an artificial control of the production of a pathogenically mutated huntingtin in HD, or in the development of a therapeutic method or agent against a selective neuronal cell death in HD.