发明名称 |
Labile linkage for compound delivery to a cell |
摘要 |
Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and have rapid hydrolysis kinetics in conditions which are present in a cell as well as in vivo. Cleavage of the acetal enhances delivery of the biologically active compound.
|
申请公布号 |
US2005054604(A1) |
申请公布日期 |
2005.03.10 |
申请号 |
US20040929707 |
申请日期 |
2004.08.30 |
申请人 |
ROZEMA DAVID B.;WAKEFIELD DARREN |
发明人 |
ROZEMA DAVID B.;WAKEFIELD DARREN |
分类号 |
A61K31/192;A61K48/00;C12N15/87;(IPC1-7):A61K48/00 |
主分类号 |
A61K31/192 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|