发明名称 |
TWO-PART DRUG DISCOVERY SYSTEM |
摘要 |
A mathematical prognostic in which changes in a number of physiologically significant factors are measured and interpolated to determine a "damage function" incident to bacterial infection or other serious inflammation, followed by either or both of in vitro or in vivo investigations of a particular active agent (drug) and adjustment of the model so as better to evaluate the particular active agent. By measuring a large number of physiologically significant factors including, but not limited to, Interleukin 6 (IL-6), Interleukin 10 (IL-10), Nitric Oxide (NO), and others, it is possible to predict life versus death by the damage function, dD/dt. To evaluate one or more drug candidates against inflammation, the mathematical model is applied first, followed by in vivo and/or in vitro investigations, and the in vivo and/or in vitro investigations are in turn used to adjust or to enhance, if applicable, the mathematical model as it is applied to the particular drug candidate. |
申请公布号 |
WO2005020796(A2) |
申请公布日期 |
2005.03.10 |
申请号 |
WO2004US27678 |
申请日期 |
2004.08.26 |
申请人 |
THE UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTHSYSTEM OF HIGHER EDUCATION;CHOW, CARSON, C.;VODOVOTZ, YORAM;CLERMONT, GILLES;FINK, MITCHELL, P.;BARTELS, JOHN |
发明人 |
CHOW, CARSON, C.;VODOVOTZ, YORAM;CLERMONT, GILLES;FINK, MITCHELL, P.;BARTELS, JOHN |
分类号 |
A61B;G01N33/48;G01N33/50;G06F19/00 |
主分类号 |
A61B |
代理机构 |
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