摘要 |
This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro- derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders. |
申请人 |
4 AZA BIOSCIENCE NV;WAER, MARK, JOZEF, ALBERT;HERDEWIJN, PIET, ANDRE, MAURITS, MARIA;PFLEIDERER, WOLFGANG, EUGEN;MARCHAND, ARNAUD, DIDIER, MARIE;DE JONGHE, STEVEN, CESAR, ALFONS |
发明人 |
WAER, MARK, JOZEF, ALBERT;HERDEWIJN, PIET, ANDRE, MAURITS, MARIA;PFLEIDERER, WOLFGANG, EUGEN;MARCHAND, ARNAUD, DIDIER, MARIE;DE JONGHE, STEVEN, CESAR, ALFONS |