| 摘要 |
FIELD: biotechnology, vaccines. ^ SUBSTANCE: invention proposes an oligomeric particle that is able to induce immunity against hepatitis C virus. Particle consists of purified proteins or their parts, hepatitis C virus envelope (HCV) E1, E1s and E2. Proposed particle has diameter from 5 to 100 nm. Also, invention proposes a method for preparing such particle. Method involves purification of proteins HCV in solution, formation of oligomeric particles by replacing purified proteins with detergent solution or salt solution and purification of oligomeric particles. Also, invention proposes a composition for inducing immunity against HCV that comprises the proposed particle, antibody specific to particle, sets for detection of antigens HCV, immunological analysis for detection of antibodies to HCV, and vaccine against hepatitis C virus (HCV) that comprises the oligomeric particle. Proposed inventions provide carrying out the induction of specific humoral and cellular immunity to HCV envelope proteins and to carry out diagnosis of HCV. Invention can be used in medicine. ^ EFFECT: valuable medicinal properties of particle, improved preparing methods. ^ 71 cl, 27 dwg, 6 tbl, 14 ex |
