| 摘要 |
The invention relates to chemiluminescent compounds of general formula: (I) wherein: either: R1 is a reactive group capable of reacting with an amine or thiol moiety; L1 is a hydrocarbon linker moiety comprising 2 - 12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aryl, fused aryl, C1-C4 alkoxy , C1-C4acyl, halide, hydroxy or nitro; or, alternatively: the combination R1-L 1- comprises a C1-C4 alkyl group optionally substituted with hydroxy, halo, nit ro or C1-C4 alkoxy; and R2 comprises a group R4-L1-, where R4 is a reactive gro up capable of reacting with an amine or thiol moiety; and L1 is as defined abov e; L2 is -C(=O)O-, -C(=O)-S- or -C(=O)N(SO2R5)-, wherein, in each case, the - C(=O) is linked to the ring carbon atom, and R5 is C1-C8 alkyl, aryl, C1-C8 alkoxy or C1-C8 acyl; R3 a substituted C1-C8 alkyl, C2-C8 alkenyl, C1-C8 alkynyl or aryl group wherein at least one of the said substituents is electron-withdrawing such that the pKa of the conjugate acid of the leaving group formed from R3 and the -O, -S or -N(SO2R5) of the L2 group is <= ab out 9.5; and X- is an anion formed as the result of the synthesis and processing of the molecule; wherein the compound may contain one or more additional R2 moieties on either or both outer rings, provided that only one of said R2 moieties may comprise an R4-L1-group.
|
