发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION |
摘要 |
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression. |
申请公布号 |
WO2005020897(A2) |
申请公布日期 |
2005.03.10 |
申请号 |
WO2004US26931 |
申请日期 |
2004.08.20 |
申请人 |
DENDREON CORPORATION;NATARAJAN, SATEESH K.;MORENO, OFIR;GRADDIS, THOMAS J.;DUNCAN, DAVID;LAUS, REINER;CHEN, FENG |
发明人 |
NATARAJAN, SATEESH K.;MORENO, OFIR;GRADDIS, THOMAS J.;DUNCAN, DAVID;LAUS, REINER;CHEN, FENG |
分类号 |
A61K31/498;A61K31/517;A61K45/06;C07C311/20;C07C311/37;C07C323/40;C07C323/44;C07C333/06;C07D207/06;C07D207/09;C07D207/32;C07D207/325;C07D209/08;C07D209/14;C07D209/20;C07D209/48;C07D213/40;C07D215/04;C07D215/08;C07D215/46;C07D217/06;C07D231/12;C07D231/14;C07D231/56;C07D235/18;C07D235/26;C07D239/42;C07D241/18;C07D241/44;C07D251/54;C07D263/34;C07D263/56;C07D263/57;C07D279/12;C07D295/096;C07D295/135;C07D295/26;C07D307/52;C07D317/66;C07D333/34;C07D401/04;C07D405/12;C07D413/04;C07D413/12;C07D417/04;C07D471/04;C07D487/04;C07D493/08;C07D495/04;C07D513/04;G01N33/68 |
主分类号 |
A61K31/498 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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