Protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
申请公布号
WO2005021582(A2)
申请公布日期
2005.03.10
申请号
WO2004US28234
申请日期
2004.08.30
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;O'BRIEN, TIMOTHY;CANNON, MARTIN, J.;BEARD, JOHN;SANTIN, ALESSANDRO;SHIGEMASA, KAZUSHI