发明名称 |
HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS |
摘要 |
Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Exampl e biodegradable unsaturated polymers include poly(propylene fumarate) and poly(.epsilon.-caprolactone-fumarate). The crosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
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申请公布号 |
CA2535857(A1) |
申请公布日期 |
2005.03.10 |
申请号 |
CA20042535857 |
申请日期 |
2004.08.27 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
YASZEMSKI, MICHAEL J.;LU, LICHUN;CURRIER, BRADFORD L.;JABBARI, ESMAIEL |
分类号 |
C08J9/00;A61F;A61L27/48;A61L27/56;A61L27/58;C08K5/00 |
主分类号 |
C08J9/00 |
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