GAMMA-BUTYROLACTONE AUTOREGULATOR RECEPTOR GENE(ESGR) ISOLATED FROM SACCHAROPOLYSPORA ERYTHRAEA AND PROTEIN EXPRESSED THEREFROM WHICH ARE USEFUL FOR STUDIES ON INDUCTION OF ERYTHROMYCIN PRODUCTION, INDUCTION OF SECOND METABOLISM PRODUCTION, AND SPORE FORMATION USING SACCHAROPOLYSPORA SP.

摘要

PURPOSE: A gamma-Butyrolactone autoregulator receptor gene(EsgR) isolated from Saccharopolyspora erythraea and a protein expressed therefrom are provided, which gene and protein are useful for studies on induction of erythromycin production, induction of second metabolism production, and spore formation using Saccharopolyspora sp. CONSTITUTION: The gamma-Butyrolactone autoregulator receptor gene(EsgR) isolated from Saccharopolyspora erythraea IFO 13426 has the nucleotide sequence set forth in SEQ ID NO:1. The protein encoded by the gamma-Butyrolactone autoregulator receptor gene(EsgR) isolated from Saccharopolyspora erythraea IFO 13426 of SEQ ID NO:1 has the amino acid sequence set forth in SEQ ID NO:2.