发明名称 |
Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis |
摘要 |
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.
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申请公布号 |
US6863887(B1) |
申请公布日期 |
2005.03.08 |
申请号 |
US20010647501 |
申请日期 |
2001.06.15 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
MURPHY GERALD P.;BOYNTON ALTON L.;SEHGAL ANIL |
分类号 |
A61K38/00;C07K14/715;C07K16/24;C07K16/28;(IPC1-7):A61K39/395;A61K51/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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