RECOMBINANT EXPRESSION OF THE HAG1 ANTIMICROBIAL PEPTIDE: USE AS FUSION PARTNER FOR THE EXPRESSION OF ALPHA HELICAL ANTIMICROBIAL PEPTIDES

摘要

This invention relates to the production of linear, cationic, amphiphilic, alpha helical, antimicrobial peptides by recombinant techniques in bacterial host cells by a method in which the peptides are fused to a specific cathelicidin-related peptide derived from the hagfish. The peptides are expressed in high yield and are easily purified either as fusion proteins or cleaved from the carrier protein for separate purification.