| 摘要 |
<p>Method for (I) where = norscopolamine, noratropine, norhyoscyamine, norscopoline, nor tropinone, or nor-4-pelletierine, and their salts. Spasmolytics Tropinone (27.8g.) in PhMe (40 ml.) was added to COCl2 (29.1g.) in PhMe (100 ml.) at 10 deg., stirred 2 d., filtered, and evaporated in vac. The residue was heated in H2O(120 ml.) until CO2 evoln. ceased, concd. in vac., and recryst. from MeCN, giving nor tropinone. HCl(20.3g.), m.p. 204 deg. (d.).</p> |
