发明名称 |
PROCESS FOR THE PREPARATION OF CEPHALOSPORIN ANTIBIOTIC |
摘要 |
<p>A process for the preparation of cephalosporin antibiotic of the formula (I) wherein R1 represents hydrogen, trityl, etc,; R3 is carboxylate ion or COORd, where Rd represents hydrogen, ester or a counter ion which forms a salt; R4 represents H, OCH3, OCOCH3, =CH2, OCONH2, etc, which comprises: (i) condensing the activated derivative of the formula (III) where X represents halogen atom, with 7-amino cephalosporin derivative of the formula (XV) wherein R represents hydrogen, lower alkyl, etc, in the presence of a solvent at a temperature in the range of -50 °C to +50 °C to produce a compound of formula (XVI) ii) maintaining the pH in the range 5.0-10.0 using an inorganic base, iii) cyclizing the compound of formula (XVI) with thiourea to produce compound of formula (I).</p> |
申请公布号 |
WO2005019227(A1) |
申请公布日期 |
2005.03.03 |
申请号 |
WO2004IB01287 |
申请日期 |
2004.04.13 |
申请人 |
ORCHID CHEMICALS & PHARMACEUTICALS LTD;PANDURANG, BALWANT, DESHPANDE;UDAYAMPALAYAM, PALANISAMY, SENTHILKUMAR;HERO, VELLADURAI |
发明人 |
PANDURANG, BALWANT, DESHPANDE;UDAYAMPALAYAM, PALANISAMY, SENTHILKUMAR;HERO, VELLADURAI |
分类号 |
C07D501/00;C07D501/06;C07D501/24;(IPC1-7):C07D501/06 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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