LISTERIA ATTENUATED FOR ENTRY INTO NON-PHAGOCYTIC CELLS, VACCINES COMPRISING THE LISTERIA, AND METHODS OF USE THEREOF
摘要
The present invention provides Listeria that are attenuated for entry into non-phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated Listeria. Some of the attenuated Listeria are mutant Listeria that comprise at least one mutation in a gene encoding an invasin, such as an internalin. Some of the attenuated Listeria are further attenuated for cell-to-cell spread. Pharmaceutical compositions and vaccines useful in the methods of the invention are further provided. Methods of making and improving vaccines are also provided.
申请公布号
WO2004110481(A3)
申请公布日期
2005.03.03
申请号
WO2004US03429
申请日期
2004.02.06
申请人
CERUS CORPORATION;DUBENSKY, THOMAS, W., JR.;BROCKSTEDT, DIRK, G.;COOK, DAVID
发明人
DUBENSKY, THOMAS, W., JR.;BROCKSTEDT, DIRK, G.;COOK, DAVID