METHOD OF EXAMINING COLON CANCER AND COLON ADENOMA

摘要

It is intended to provide an examination method useful in diagnosing colon cancer and colon adenoma whereby a patient suffering from colon cancer and a patient with a high risk of colon cancer can be detected at a high ratio, an d an examination reagent therefor. A remarkable difference in the distribution of sugar chain sulfating enzyme GlcNAc-6-sulfotransferase isozymes is found out between a noncancerous colon tissue and a colon cancer tissue/a colon adenoma tissue. Then, it is clarified that colon cancer and colon adenoma ca n be specifically detected by detecting GlcNAc-6-sulfated sugar chains in a definite range from tissues or fecal samples of patients by applying the abo ve difference. By using MECA-79 antibody (Pharmingen Catalog No. 09961D, Becton Dickinson) reacting with GlcNAc-6-sufated sugar chains specifically formed b y enzymes occurring in colon cancer and colon adenoma, colon caner and colon adenoma can be examined.