| 摘要 |
Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleid acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes. |
| 申请人 |
AMGEN, INC.;ISIS PHARMACEUTICALS, INC.;DOBIE, KENNETH, W.;BHANOT, SANJAY;VENIANT-ELLISON, MURIELLE;LINDBERG, RICHARD, A.;SHUTTER, JOHN, R. |
发明人 |
DOBIE, KENNETH, W.;BHANOT, SANJAY;VENIANT-ELLISON, MURIELLE;LINDBERG, RICHARD, A.;SHUTTER, JOHN, R. |
