发明名称 |
Orally administrable acid stable anti-ulcer benzimidazole derivatives |
摘要 |
Orally administrable acid stable anti-ulcer benzimidazole derivatives which are polymer based. The process of preparation comprises condensing a benzimidazole with a biocompatible partially orally biodegradable synthetic cross linked polymer in aqueous medium at 5-80° C. and pH 4-11 under inert atmosphere. The weight percentage of benzimidazole with respect to the polymeric benzimidazole is 1-50. The reaction mixture is cooled and the product is isolated and dried at 25-45° C. There is also provided a formulation of the polymeric benzimidazoles in combination with pharmaceutically acceptable excipients. |
申请公布号 |
AU2000254245(B2) |
申请公布日期 |
2005.03.03 |
申请号 |
AU20000254245 |
申请日期 |
2000.02.24 |
申请人 |
KOPRAN RESEARCH LABORATORIES LIMITED |
发明人 |
KAMLESH RANBHAN;JAYANT DESHPANDE;RAJAN GUPTE;SUBHASH MALI |
分类号 |
C07D401/12;A61K9/22;A61K31/4184;A61K31/4439;A61K31/787;A61K47/12;A61K47/26;A61K47/32;A61K47/38;A61K47/48;A61P1/04;C08F8/34;C08F20/00;(IPC1-7):A61K031/418;A61P001/04 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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