发明名称 |
NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
摘要 |
The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at,least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated P-adrenergic antagonists, nitrosated and/or nitrosylated angiotensinconverting enzyme (ACE) inhibitors, nitrosated and/or nitrosylated anti-hyperlipidemic compounds, and nitrosated and/or nitrosylated antithrombotic and vasodilator compounds. |
申请公布号 |
WO2005018561(A2) |
申请公布日期 |
2005.03.03 |
申请号 |
WO2004US26909 |
申请日期 |
2004.08.20 |
申请人 |
NITROMED, INC.;GARVEY, DAVID, S.;LETTS, GORDON, L.;WORCEL, MANUEL;GASTON, RICKY, D. |
发明人 |
GARVEY, DAVID, S.;LETTS, GORDON, L.;WORCEL, MANUEL;GASTON, RICKY, D. |
分类号 |
A61K;A61K31/405;A61K31/44;A61K31/535;C07D209/04;C07D221/02;C07D415/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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