发明名称 |
TARGETING POLYPEPTIDES TO THE CENTRAL NERVOUS SYSTEM |
摘要 |
The invention provides a chimeric CNS targeting polypeptide having a BBB-receptor binding domain and a payload polypeptide domain. The chimeric CNS targeting polypeptide can have a BBB-receptor binding domain consisting of a receptor binding domain from ApoB, ApoE, aprotinin, lipoprotein lipase, PAI-1, pseudomonas exotoxin A, transferrin, alpha2-macroglobulin, insulin-like growth factor, insulin, or a functional fragment thereof. Nucleic acids encoding a chimeric CNS targeting polypeptide are also provided. Further provided is a method of delivering a polypeptide to the CNS of an individual. The method consists of administering to the individual an effective amount of a chimeric CNS targeting polypeptide, said chimeric CNS targeting polypeptide comprising a BBB-receptor binding domain and a payload polypeptide domain. The method also can deliver a polypeptide to the lysosomes of CNS cells. |
申请公布号 |
WO2004108071(A3) |
申请公布日期 |
2005.03.03 |
申请号 |
WO2003US34974 |
申请日期 |
2003.10.31 |
申请人 |
SALK INSTITUTE FOR BIOLOGICAL STUDIES;VERMA, INDER, M.;SPENCER, BRIAN |
发明人 |
VERMA, INDER, M.;SPENCER, BRIAN |
分类号 |
A61K;A61K38/02;A61K38/28;A61K38/30;A61K47/48;C07H21/04;C07K14/47;C12N9/10;C12N9/16;C12N15/62 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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