发明名称 |
METHODS AND COMPOSITIONS FOR CORRECTION OF CARDIAC CONDUCTION DISTURBANCES |
摘要 |
The invention provides methods for establishing electrical coupling between cardionyocytes and recombinant cells which have been genetically engineered to express a gap junction protein, eg., Connexin protein such as Connexin 43 (CX43) protein, n invention is based on the discovery that genetic modification of skeletal muscle cells to express a recombinant connexin, enables the genetically modified cells to establish electrocommunication with cardiac cells via gap junctions. The recombinant connexin-expressing cells can be used for repair of cardiac issue and for treatment of cardiac disease by transplantation into cardiac tissue. |
申请公布号 |
EP1509252(A2) |
申请公布日期 |
2005.03.02 |
申请号 |
EP20030728752 |
申请日期 |
2003.05.07 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LEE, RANDALL J.;MACIEJEWSKI, MARK I. |
分类号 |
A61N1/05;A61B;A61B17/00;A61F2/84;A61K35/12;A61K35/36;A61K48/00;A61M25/00;A61M25/10;A61M31/00;A61P9/06;C12N5/02;C12N5/071;C12N5/077 |
主分类号 |
A61N1/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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