发明名称 |
Transcriptional intermediary factor-2 |
摘要 |
The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.
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申请公布号 |
US6861508(B2) |
申请公布日期 |
2005.03.01 |
申请号 |
US20010842256 |
申请日期 |
2001.04.26 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE LOUIS PASTEUR;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHAMBON PIERRE;GRONEMEYER HINRICH;VOEGEL JOHANNES;LUTZ YVES |
分类号 |
C07K14/47;C12N15/12;(IPC1-7):C07K14/00 |
主分类号 |
C07K14/47 |
代理机构 |
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