发明名称 |
METHOD FOR ISOLATING PHARMACEUTICALLY EXPLOITEABLE ETIDRONATE DISODIUM |
摘要 |
The method of isolating an anhydrous etidronate disodium particulate includes preparing a liquid-liquid dispersion consisting of an aqueous-organic phase and an etidronate-disodium-salt-containing aqueous phase; adjusting a temperature of the liquid-liquid dispersion to between 0 and 30° C. and intensely agitating so that a coarse-particle fraction precipitates from the liquid-liquid dispersion, then drawing off a fine-particle suspension and allowing a fine-particle fraction to precipitate from it and filtering and drying the coarse particle fraction. In a preferred embodiment the fine-particle fraction is separated from the fine-particle suspension for recycling The resulting anhydrous etidronate disodium particulate has a grain size of from about 0.1 to 1 mm and a bulk density of 0.4 to 0.6 g/cm<SUP>2 </SUP>with good properties for pharmaceutical applications. |
申请公布号 |
HU0301226(A3) |
申请公布日期 |
2005.02.28 |
申请号 |
HU20030001226 |
申请日期 |
2001.09.28 |
申请人 |
SCHERING AKTIENGESELLSCHAFT, BERLIN |
发明人 |
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分类号 |
C07F9/38 |
主分类号 |
C07F9/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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