| 摘要 |
The invention relates to method for the preparation of citalopram, comprising reduction of the oxo group of a compound of formula wherein R1 is CN, C1-6 alkyloxycarbonyl. There follows ring closure of the resulting hydroxy compound whereby obtaining the corresponding 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran, then if R1 is cyano group, using it directly in the next step, and if R1 is C1-6 alkyloxycarnonyl, or C1-6 alkylaminocarnbonyl. Then the compound is converted to the corresponding compound wherein R1 is cyano and the produced 5-cyano compound is alkylated with 3-dimethylaminopropylhalogenide in basic conditions thereby obtaining citalopram.
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