发明名称 COMPOUNDS WITH HYDROXYCARBONYL-HALOGENALKYL BY-SIDE CHAINS
摘要 FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to a new compound of the general formula (2) and a method for its preparing wherein R1 represents hydrogen atom or salt-forming metal; R2 represent a direct or branched (C1-C7)-halogenalkyl group; m represents a whole number from 2 to 14; n represents a whole number from 2 to 7; A represents a group taken among the following formulae: (3) , (4) , ^ (5) , ^ (6) , ^ (17) , (18) , (19) , (20) , (23) , (25) and (26) wherein R3 in formula (6) represents a direct or branched group (C1-C5)-alkyl group; R8 in formulae (18) and (20) represents a direct or branched (C1-C5)-alkyl group, a direct or branched (C2-C5)-alkenyl group or a direct or branched (C2-C5)-alkynyl group; in formula (23) each R21, R22, R23 and R24 represents independently hydrogen atom, a direct or branched (C1-C5)-alkyl group, a direct or branched (C1-C7)-halogenalkyl group, halogen atom or acyl group; in formulae (25) and (26) X represents halogen atom; or enantiomers of compound, or hydrates, or pharmaceutically acceptable salts of compound, or its enantiomers. Also, invention relates to a pharmaceutical composition containing indicated compound as an active component and to a therapeutic agent used against breast cancer based on thereof. ^ EFFECT: valuable medicinal properties of compounds. ^ 10 cl, 2 tbl, 39 ex
申请公布号 RU2247106(C2) 申请公布日期 2005.02.27
申请号 RU20020118710 申请日期 2000.12.13
申请人 发明人 DZO DZAE CHON;KVON KHEE AN;LIM KHIUN SUK;CHOJ DZAE JANG;MORIKAVA KAZUMI;KANBE ESITAKE;NISIMOTO MASAKHIRO;KIM MIUNG KHVA;NISIMURA ESIKAZU
分类号 C07C59/56;A61K31/20;A61K31/381;A61K31/538;A61K31/565;A61P5/32;A61P35/00;C07D209/12;C07D265/36;C07D303/18;C07D311/60;C07D333/56;C07J1/00 主分类号 C07C59/56
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