Peptide and peptidomimetic antagonists of a G protein coupled receptor in treatments for regulating fluid filtration in the kidney

摘要

Compositions comprised of matter comprising novel prostaglandin E2 receptor antagonists are described, and their use in treatments for regulating the fluid filtration in the kidney, preventing bone mineral loss in osteoporosis and dental disease and additionally, closure of ductus arteriosus (DA) in premature infants or foetal animals. Additionally, the compositions include linear peptides, peptide analogues and peptidomimetics.