摘要 |
Mikanolide derivatives, their preparation and their therapeutic uses are disclosed. The compounds correspond to general formula (I) corresponding to general sub-formulae (I)1 and (I)2, wherein: R1 represents H, SR4 or NR4R5; R2 represents SR6 or NR6R7; R3 represents OH, O(CO)R14, OSiR15R16R17, O(CO)OR18 or O(CO)NHR18, each of the radicals R4, R6, R15, R16 and R17 representing independently (in particular) an alkyl radical, the radicals R5 and R7 representing (in particular) radicals selected independently from a hydrogen atom and an alkyl radical, and each of the radicals R14 and R18 representing independently (in particular) an alkyl or cycloalkyl radical, or one of aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)2, then R1 does not represent a hydrogen atom. The compounds disclosed are used in the manufacture of a medicament intended to inhibit DNA polymerases, to treat diseases due to abnormal cell proliferation, to treat cancer, to treat atherosclerosis, benign hyperplasia of the prostate and fibroses, to treat viral diseases, to treat parasitic diseases or to treat diseases of bacterial origin.
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