| 摘要 |
1,205,026. Steroido-oxazolines. GRUPPO LEPETIT S.p.A. 3 Jan., 1968 [13 Jan., 1967], No. 1900/67. Heading C2U. Novel compounds of formula (wherein R is H, OH or acyloxy and R<SP>1</SP> is H, phenyl or C 1-8 alkyl) are prepared from the corresponding 11-unsubstituted steroids by the action of enzymes produced in the fermentation of a fungus of the class Fungi imperfecti or Phycomycetes, e.g. Curvularia lunata, Cunning- hamella blakesleeana or Absidia orchidis. 11#,21 - Dihydroxy - 2<SP>1 </SP>- methyl - 5<SP>1</SP>#H - 1,4 - pregnadieno[17,16-d]oxazole- 3,20 - dione 21 - acetate is prepared by dehydrogenating the corresponding 4-pregnene with Corynebactemrui simplex. 21 - Hydroxy - 2<SP>1</SP>- methyl - 5<SP>1</SP>#H - 4 - pregneno- [17,16-d]ozazole - 3,20 - dione 21 - acetate is prepared from 3-hydroxy-2<SP>1</SP>-methyl-5<SP>1</SP>(#H-5- pregneno[17,16-d]oxazol-20-one via 3-hydroxy- 21 - iodo - 2<SP>1</SP>- methyl - 5<SP>1</SP>#H - 5 - pregneno[17,16- d]oxazol-20-one and 3,21-dihydroxy-2<SP>1</SP>-methyl- 5<SP>1</SP>#H - 5 - -pregneno[17,16 - d]oxazol - 20 - one 21 - acetate. The novel compounds are said to possess antiinflammatory, hormone-like and gluconeogenetic activity and may be made up with carriers into pharmaceutical compositions.
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